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In 2010, the National Research Council published the report U.S-Iran Engagement in Science, Engineering, and Medicine (2000-2009). The review of the program described in detail the National Academies' science, technology, and health cooperation program carried out jointly with partners in Iran (otherwise known as science-engagement).The purpose of this new publication is to document the history and details of the National Academies' program of science-engagement from 2010 through 2016, while providing a perspective in considering future science-engagement. A variety of cooperative activities, and particularly workshops that dominated science-engagement during that period, are highlighted.Table of ContentsFront MatterSummary1 Introduction2 Context for Science-Engagement Activities3 Program Activities from 2010 to 20164 Overcoming Barriers to Cooperation5 Uncertain Future for Science-EngagementAppendix A: Timeline for Selected Activities of the NationalAcademies of Sciences, Engineering, and Medicine (1999-2016)Appendix B: Workshop Proceedings and Other Documents about MeetingsSponsored by the National Academies of Sciences, Engineering, andMedicine (1999-2016)Appendix C: Strategic Science and Technology Approaches of Iran(2015)Appendix D: Key Science and Technology Policies of Iran (2010-2016)Appendix E: National Academies of Sciences, Engineering, andMedicine's Search of Scopus Data Base for Iranian Publications(2014)Appendix F: Project Opportunities Identified during Workshop onClimate Change (2015)Appendix G: Management of Land and Water Resources: Lessons Learnedfrom Alborz Pilot Effort Supported by World Bank (2005-2013)Appendix H: Selected Provisions of Annex III of the JointComprehensive Plan of Action: Civil Nuclear Cooperation (2015)Appendix I: European Union Agreements with Iran on Cooperation inScience and Technology (2016)Appendix J: Priority Environmental Interests of Supreme Leader andOpportunities for Cooperation (2015)