Translating Mechanisms of Orofacial Neurological Disorder

Estrogen Inflammation Neurobiology Neurons Local anesthesia Neocortex Animal models Mastication Amino acids Ultrastructure Orofacial pain Tardive dyskinesia Hyperalgesia Optical Imaging animal model Peripheral nerve injury Postnatal development Craniofacial Knockout mice Targeted delivery Voltage-sensitive dye Sensitization Gustatory Pain control Glia FOS Nociception Behavioral pharmacology Insula Neurotransmitter Neuropathic Pain Limbic Critical period Temporomandibular CGRPcalcitonin gene-related peptide DCVdense-cored vesicle central pattern generation EMelectron microscope EPSPexcitatory postsynaptic potential ChATcholine acetyltransferase Ethogram Dopamine receptor subtypes Dopamine D1-like/D2-like receptors clinical manifestations of orofacial neuropathic pain ending presynaptic to primary afferent terminal GABA receptor subtypes CNScentral nervous system GABAergic interneuron GADglutamic acid decarboxylase FRAPfluoride-resistant acid phosphatase GABAγ-aminobutyric acid IB4isolectin B4 Descending modulation Dopamine receptor transduction IRtintermediate reticular formation DRGdorsal root ganglion JOjaw-opening Jaw movements Incisor movements intrinsic bursting mGluR5metabotropic glutamate receptor 5 Nucleus accumbens shell Orofacial dyskinesia PADprimary afferent depolarization Glutamate receptor subtypes PCPacinian corpuscle P-endingpresynaptic ending HRPhorseradish peroxidase HTMhigh-threshold mechanoreceptive P2X3P2X purinoceptor 3 Pdproximal dendrite peripheral presynaptic modulation RArapidly-adapting jaw muscle rhythmogenesis QX-314 LTMlow-threshold mechanoreceptive JCjaw-closing Inflammatory pain trigeminal spinal sub-nucleus caudalis Trp TGtrigeminal ganglion Vmestrigeminal mesencephalic nucleus Vmotrigeminal motor nucleus Tongue movements VPMventroposteromedial nucleus of thalamus Trigeminal MSmuscle spindle Vmo.dldorsolateral part of Vmo Vtrspinal trigeminal tract Vodmdorsomedial part of Vo PATsprimary afferent terminals PCRtparvocellular reticular formation NMDA receptors NP-Yneuropeptide Y pulpal axon Orofacial movements SAslowly-adapting PLperiodontal pain hypersensitivity SPsubstance P Trigeminal transitions zone TRPA1transient receptor potential ankyrin 1 TSNtrigeminal sensory nuclei Vctrigeminal caudal nucleus Votrigeminal oral nucleus trigeminal ganglion Trigeminal Neuropathic Pain TRPV1transient receptor potential vanilloid 1 Vitrigeminal interpolar nucleus Vmo.vmventromedial part of Vmo Vptrigeminal principal nucleus Vsupsupratrigeminal nucleus synaptic connectivity Vo.rrostrodorsomedial part of Vo WGAwheat germ agglutinin Vdmdorsomedial part of Vi and Vo Ventrolateral striatum Vidmdorsomedial part of Vi XIImohypoglossal nucleus