The 2020-21 Guide to Medications for the Therapy of Diabetes Mellitus

Newly updated to reflect the latest research and medical guidance, the 2020-21 Guide to Medications for the Treatment of Diabetes offers a bridge between drug handbooks and pharmacology texts.Focusing entirely on diabetes drugs, this reference is divided into two sections:Drugs used to manage hyperglycemia, andManagement of diabetic comorbidities.The first section includes:Pharmacologic Therapy for Type 1 DiabetesManagement of Hyperglycemia in Type 1 DM- info from practical use of insulin, pathophysiology, treatment strategyInsulins: RAIAs, Short-acting insulins, intermediate-acting insulins, LAIAs, Concentrated Insulins, Insulin pumps and patches, inhaled insulins, mixed and mixing insulin, use in Type 1, use in Type 2Pharmacologic Therapy for Type 2 DiabetesManagement of Hyperglycemia in Type 2- brief overview, pathophysiology, treatment strategy, overview of medicationsBiguanidesTZDsSUsGlinidesSGLT-2 InhibitorsAGIsDPP-IV inhibitorsGLP RasAmylin mimeticsBARsDA-2 agonistsEach chapter in Section 1 includes:Drug class overview and role in diabetes treatmentPharmacology: a. Mechanism of action, b. PharmacokineticsTreatment Advantages/Disadvantages: General for the class, b. When applicable, a discussion of evidence that supports the benefits of using a particular drug in a class over another in the same class (eg, Avandia vs Actos)Therapeutic Considerations: a. Significant Warnings/Precautions, b. Special Populations, c. Pharmacogenomics, d. Adverse effects and monitoring, e. Drug Interactions, f. Dosage and administrationTable with Doses and Dose AdjustmentsList of important combination productsReferencesThe second section includes:Cardiovascular Disease and Risk ManagementMicrovascular Complications and Foot CareMedications for the Management of HypertensionMedications for the Management of HyperlipidemiaAntiplatelet TherapyMedications for Smoking CessationMedications for the Management of Neuropathy (peripheral and autonomic)Medications for the Management of NephropathyMedications for the Management of RetinopathyMedications for the Management of DepressionMedications for the Management of HypoglycemiaMedications for the Management of ObesityImmunizations in Patients with DiabetesEach chapter in Section 2 includes:An overview of the condition or problemGoals of treatmentOverview of the medications and rationale for the medications used for the problemOverview of each class of medicationOverview of combination therapy: a. first combination, b. second combinationDoses and Dose Adjustments for the more salient medicationsList of important combination productsReferences