Sterile Filtration

This book focuses on sterilizing grade filters in the biopharmaceutical industry, emphasizing practical applications of universal and dependable operational protocols, integrity testing, and troubleshooting to streamline the production and preparation of pharmaceuticals.

Addresses the complexities of globalizing redundancy in filtration!

Enabling educated developmental, procedural, and regulatory judgments to be made in the manufacturing of sterile health care products, Sterile Filtration

considers how many filters should be in the process stream

examines the existence of nanobacteria and viable but nonculturable organisms

covers pore size designations, distributions, architecture, and numbers

discusses the latest findings in bubble point and diffuse flow measurements

describes pre- and postfiltration, up- and downstream testing, and after-stream sterilizations

details wetting liquid, polymer, temperature, and water purity effects

explains sieve retention, size exclusion, adsorptive sequestrations, charge-related phenomena, gravitational settling, and interference factors in liquids and gases

outlines filter validation, requirements, and operational specifics

and more!

Advocating separation in addition to physical destruction of microorganisms, Sterile Filtration is a reference essential for pharmaceutical scientists; biotechnologists; microbiologists; virologists; process and chemical engineers; plant, production, validation, and quality control managers in the pharmaceutical and biotechnology industries; and upper-level undergraduate and graduate school students in these disciplines.