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Beskrivelse
Natural medicines are derived from natural sources such as plants, animals and/or mineral origins. The use of traditional natural products is an empirical healthcare system based on thousands of years of human experience. Over the past few decades, quality control and safety evaluation methods for natural products, though sophisticated and technologically advanced, still lack comprehensiveness and practicability to some extent. Generally, those methods fully satisfy the modern scientific requirements for extraction, identification, purity, quality and pharmacological effects in the assessment of chemical drugs. However, they are not suitable for handling the complex chemical characteristics of natural products. Therefore, a better understanding of the basic properties of natural medicines and advanced chemical, pharmacological and biological techniques would facilitate the application of the natural products in public health.The purpose of this book is to address the issues mentioned above and present related solutions. The book covers the below topics:Advanced analytical technologies in the application of the natural medicines (e.g. mass spectrometry, gas or liquid chromatography, and NMR).Recent advances in biochemistry research of natural medicines (e.g. gene expression microarray, tissue microarray, and chromatin-precipitation assay)Innovations in analytical chemistry of natural products Quality control and safety evaluation of traditional medical material and finished productsDetection of low quality and adulterants of natural productIdentification of the plant by various analytical techniquesRegulations and management of natural products from foreign countriesNovel cell-based models used for the high-throughput screening for drug discovery in natural productsPharmacological effects of natural products in vitro and in vivoAdvanced modeling techniques used in pharamcokinetic and pharmacodynamic properties of natural products (e.g. Pharsight WINNONLIN, Simcyp, and Gastroplus)