Quadruplex Nucleic Acids As Targets For Medicinal Chemistry

DNA Cancer Metal complexes Biophysics Telomerase Molecular probes Transcription factors Equilibrium Toxicity Metabolism Transcription Optical images Structure Chromatin Telomere Mitochondria Topology RNA NMR X-ray Diversity Click Chemistry Fluorescent Dyes Translation Recombination Antiviral Therapy Live cell imaging Force Fields Molecular Dynamics Simulations MYC Epstein-Barr virus (EBV) Oncogene Folding Anticancer agent Antibody Chronic infection Fluorophores Retrovirus Optical probes RNA virus C-kit Double-stranded DNA Biological activity Kit Ligand binding Translational studies Pancreatic Ductal Adenocarcinoma Cancer therapy Inhibitor Single-molecule FRET Latency Polymorphism G-quadruplex Immunodetection AGCGA-quadruplex Alternative lengthening of telomere (ALT) Antigenic stimulation Binding Mode cation Conformational profile DNA ligands elements Chemotype diversity DNA Virus Clinical approval Enhanced-sampling methods G4-specific bisbiguanidine effector molecules G4-decoy oligonucleotides down-regulating KRAS in cancer cells G4-specific indoloquinoline derivatives i-motif EBV-related cancers Loop dynamics Metallo-drugs G-quadruplex (Quadruplex) g4 Nucleolin G4-ligands G4 selective ligands Non-canonical nucleic acid structure G-quadruplex RNA Quadruplex-DNA Quadruplex ligand binding proto-oncogene Quadruplex Quadruplex drug Kirsten ras (KRAS) proto-oncogene Quadruplex-selective ligand Small molecules interfering with translation: anthrathiophenediones and cationic porphyrins Structure of NHE G4s: G4(21R) and G4(32R) uptake Kinetic partitioning of quadruplex folding landscape Proteins recognizing the KRAS G4 structures Triazole Target-guided synthesis Virus Life Cycle