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Beskrivelse
Pyrazolo Pyrimides-Based Drug Discovery describes the medicinal attributes of all isomeric forms of pyrazolopyrimidines with special emphasis on their structure activity relationship (SAR). Pyrazolopyrimidines play an important role in organic and medicinal chemistry as they act as a bridge between life sciences and biochemical investigations. Pyrazolopyrimidines are essential scaffolds for generating a wide range of chemical libraries and drug-like candidates to obtain desired therapeutic and pharmacological activity. Specific functional groups are covered, as well as synthesis of bioactive compounds against a specific pathological condition. Isomeric forms of pyrazolo pyrimidine including pyrazolo 5,1-b]pyrimidines, pyrazolo 5,1-a]pyrimidines, pyrazolo 4,3-d]pyrimidines, pyrazolo 1,5-c]pyrimidines and pyrazolo 3,4-d]pyrimidines are discussed, and the discovery of pyrazolopyrimidine-based drug candidates is facilitated by coverage of essential information on functionalization and its effects. This book is ideal for researchers working in organic and medicinal chemistry both in academia and industry.