Practical Process Research & Development

This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine

chemical, and agricultural chemical industries. Process R&D describes the steps taken, following synthesis and evaluation, to bring key

compounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates are

identified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists, and

academicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process R&D. Current books do not describe hands-on, step-by-step, approaches to solving process development problems, including route, reagent,

and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." "Practical Process Research and Development" will be a valuable resource for researchers, managers, and graduate students.

* Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules"

* Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more

* Includes over 100 tips for rapid process development

* Presents guidelines for implementing and troubleshooting processes