Molecular Dynamic Simulation Studies

Mdm2 has been identified as a p53 interacting protein towards represses p53 transcriptional activity.Mdm2 achieves this repression by binding to P53 and blocking the N- terminal transactivation domain of p53. Mdm2 is a p53 responsive gene that is; its transcription can be activated by p53. When p53 is stabilized, the transcription of Mdm2 is also induced, resulting in higher mdm2 protein levels causing recognition and repair, transcription regulation problems leading to cancer. Thus inhibiting the mdm2- p53 interactions has been proven to be most promising approach for cancer therapy.