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    Molecular Biology of B Cells

    Molecular Biology of B Cells

    Forfatter: info mangler
    Bog
    • Format
    • Bog, hardback
    • Engelsk

    Beskrivelse

    Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics.

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    Detaljer
    • SprogEngelsk
    • Sidetal600
    • Udgivelsesdato11-11-2014
    • ISBN139780123979339
    • Forlag Academic Press Inc
    • FormatHardback
    Størrelse og vægt
  • Vægt2330 g
    • coffee cup img
    10 cm
    book img
    21,6 cm
    27,6 cm

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    Leukemia Symbiosis Gene expression. Inflammation Immunodeficiency Lymphoma Oncogenes Transcription factors Transcription Autoimmunity Protection Homeostasis B cells Mutualism Cytokines Carcinogenesis Pathogenicity Rheumatoid arthritis Chemokines Bone marrow Immunotherapy Immunogenetics Immunoinformatics Neutralization Epigenetics Interleukin-17 aid Microbiota MicroRNA Transposition Autoimmune Next generation sequencing Somatic hypermutation Transcription factor Immunoglobulin Lymphocyte development Regulatory T cells Microbiome RSS Diversification Humoral immunity Th17 cells Immune regulation Adaptor proteins Antibody Class switch recombination Mucosa Biologic therapy Tumor suppressor genes B cell activation Adhesion molecules Mutations? Exaptation Polymerase Post-transcriptional regulation Rearrangement Transcriptional regulation B-cell BCR Recombination activating gene B cell development RAG Site-specific recombination 3D structure TNF April Immune Repertoire Antibody repertoire Monoclonal antibody Lymphocyte Envelope CD22 Nanocluster Commensal Activation-induced cytidine deaminase (AID) Affinity Maturation AID mutations in N- and C-terminal regions AID cofactors Antibody humanization antigen receptor Autoreactivity B cell migration B cell antigen receptor (BCR) signaling B cell subpopulations B1a B cells BAFF B-cell subsets B lineage commitment B-1 B cells Ca2+ response B cell lineage commitment B cell malignancy CD19 Cleaved end pairing B cell survival B cell tolerance Class switch recombination (CSR) Cytokine signaling Coreceptors Dendritic cells (DCs) Double-strand break response Combinatorial diversity Gene conversion Gut-associated lymphoid tissue (GALT) glycan Germline transcription IMGT-ONTOLOGY Immunoglobulin A (IgA) Germinal center IMGT DNA Transposon Interleukin-10 Interleukin-6 Jawless vertebrate Interleukin-23 Epigenetic Marking Innate lymphoid cells (ILCs) Lamina propria (LP) Interleukin-35 Leucine-Rich repeat Mesenteric lymph nodes (MLNs) Lymphotoxin (LT) Lamina Propria Follicular B cells Follicular dendritic cell (FDC) Follicular dendritic cells (FDCs) Msh2 Mucosal tissues Genetic alteration Marginal zone B cells Mismatch Repair nonhomologous end joining Peyer's patches (PPs) Horizontal transfer Plasma cell Non-canonical function of UNG IMGT Colliers de Perles gp120 gp41 Recombination signal sequence IMGT unique numbering Primary antibody deficiencies Protein islands Phosphoinoisitide 3-Kinase Processing of nick to double-strand break Recombination activating genes (RAG) PTK Junctional diversity Proliferation and differentiation Secondary Lymphoid Organs T cell-dependent (TD) Stromal cells (SCs) Spondyloarthropathy Tertiary lymphoid organs Microarray expression analysis T cell-independent (TI) Regulation of AID transcription Msh6 Non-B DNA Topoisomerase 1 Transformation of B cells Translesional error-prone polymerases Syk Uracil DNA Glycosylase TACI Target specificity Translocations Somatic hypermutation (SHM) Transitional B cells Variable lymphocyte receptor V(D)J recombination
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