Lysosomes and Lysosomal Diseases

Calcium Processing Confocal microscopy Macrophage Electrophysiology Phagocytosis Endocytosis Biosynthesis Flow cytometry Lysosomes Fluorescence microscopy Microscopy Electron microscopy Antigen Presentation Autophagy Fluorescence Immunofluorescence Subcellular fractionation Galectins Method Membrane fusion Disease Progression PH Laboratory diagnosis Fluorescent proteins Quantitative analysis Lysosomal cell death Targeting Optical microscopy Acid sphingomyelinase Endosome High-content screening RNAi Intracellular trafficking Lysosome Transcriptional regulation Voltage Clamp Immunostaining Biomarker Vesicle trafficking Metabolic labeling Phagosome maturation Ion channel Particle Cholesterol homeostasis Cell Injury Filipin Autofluorescence Single-channel Assessing therapeutic efficacy Ca2+GPN Ca2+-release Cathepsins Cellular assay CD1 Ca2+Endoplasmic reticulum Cell wounding Bafilomycin A1 Content mixing Dual-wavelength ratio imaging Dendritic cell Endolysosome Death pathway CLEAR network Exocytosis of lysosomes Fluorogenic sensors Immune precipitation Intracellular cholesterol Late endosome Lysosomal enzyme Lysosomal membrane permeabilization LMP Lysosomal clearance LysoTracker LAMP1 Fluorescein Isothiocyanate NPC2 Lysosomal dysfunction Lysosome patch clamping Lysosome trafficking MHC II NAADP Niemann-Pick C disease phagocyte Plasma membrane resealing Inositol trisphosphate receptor Relative lysosomal volume shRNA Lysosomal exocytosis Storage material accumulation TFEB methods TPC2 Intracellular microbes TPC1 Ion channel reconstitution Two-pore channels Lysosomal biogenesis Lysosomal purification Lysosome function Plasma membrane repair lysosomal storage disease Nigericin Membrane traffic NPC1 Planar phospholipid bilayer RNAi screen Superparamagnetic nanoparticle Secretion of lysosomal enzymes TFEB Thresholding image analysis