Interactions of Plasticizers with Physiologically Important Proteins

The book gives a detailed account on the research conducted in our laboratory on ubiquitous xenoestrogenic plasticizers specifically the mode of binding and probable biological effects. The study was focused on exploring and defining new target molecules of the BPA and phthalates based on experimental as well as modeling and docking studies. Identification of probable biological targets of synthetic xenoestrogens Bisphenol-A and phthalates were accomplished using Enzyme Inhibition studies, x-ray crysttalography and/or Insilco modeling. Interactions of these xenoestrogens with proteins Super oxide dismutase (SOD), Glucocorticoid Receptor (GR), pancreatic phospholipase A2 (PLA2) have been studied.