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Insulin resistance, also known as impaired insulin sensitivity, happens when cells in your muscles, fat and liver don't respond as they should to insulin, a hormone your pancreas makes that's essential for life and regulating blood glucose (sugar) levels. Insulin resistance can be temporary or chronic and is treatable in some cases.
Under normal circumstances, insulin functions in the following steps:
Your body breaks down the food you eat into glucose (sugar), which is your body's main source of energy.
Glucose enters your bloodstream, which signals your pancreas to release insulin.
Insulin helps glucose in your blood enter your muscle, fat and liver cells so they can use it for energy or store it for later use.
When glucose enters your cells and the levels in your bloodstream decrease, it signals your pancreas to stop producing insulin.
For several reasons, your muscle, fat and liver cells can respond inappropriately to insulin, which means they can't efficiently take up glucose from your blood or store it. This is insulin resistance. As a result, your pancreas makes more insulin to try to overcome your increasing blood glucose levels. This is called hyperinsulinemia.
As long as your pancreas can make enough insulin to overcome your cells' weak response to insulin, your blood sugar levels will stay in a healthy range. If your cells become too resistant to insulin, it leads to elevated blood glucose levels (hyperglycemia), which, over time, leads to prediabetes and Type 2 diabetes.
A resistance to the hormone insulin, resulting in increasing blood sugar.
The hormone insulin helps control the amount of sugar (glucose) in the blood. With insulin resistance, the body's cells don't respond normally to insulin. Glucose can't enter the cells as easily, so it builds up in the blood. This can eventually lead to type 2 diabetes.
Insulin resistance typically has no symptoms.
Weight loss and exercise can help reverse insulin resistance.
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