In search of molecular domains

Brain information processing depends on appropriately integrating excitatory and inhibitory neural signals as circuits. GABA (A) receptors act as gateways for the inhibitory singnals in the mammalian brain. The diversity and dynamics of these gateways is not only a prominent factor that provides single neurons great computational power but also important for neural plasticity. By the use of recombinant DNA technology, the present study explores the factors involved in the differential cell membrane localization of GABA (A) receptor subtypes.