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I Ching(Yi Jing) created from keen observation of the nature in the universe.The Yin and Yang duality correlate with the Matter duality in Quantum Mechanics.The Trigram correlates with the Codon in DNA/RNA.The four phenomena correlate with the four chemicals in DNA/RNA.The 64 Hexagrams correlate with the 64 Codons in DNA/RNA.The primary 64 trigrams correlate with the 64 codons in DNAThe secondary 64 trigrams correlate with the 64 codons in RNA. I Ching apply the scientific wisdom to give advice in issues of dilemma wisely and accurately for oracle usage.