Human Toxicology of Chemical Mixtures

In this important reference work, Zeliger catalogs the known effects of chemical mixtureson the human body and also proposes a framework for understanding and predicting theiractions in terms of lipophile (fat soluble) / hydrophile (water soluble) interactions. Theauthor's focus is on illnesses that ensue following exposures to mixtures of chemicalsthat cannot be attributed to any one component of the mixture. In the first part the mechanisms of chemical absorption at a molecular andmacromolecular level are explained, as well as the body's methods of defending itselfagainst xenobiotic intrusion. Part II examines the sources of the chemicals discusssed,looking at air and water pollution, food additives, pharmaceuticals, etc. Part III, whichincludes numerous case studies, examines specific effects of particular mixtures onparticular body systems and organs and presents a theoretical framework for predictingwhat the effects of uncharacterized mixtures might be. Part IV covers regulatoryrequirements and the need to adjust recommended exposure levels for productscontaining mixtures. It also contains recommendations on how to limit exposure tomixtures in the products we use and on how to limit release of mixtures into theenvironment. Providing brief summaries of each mixture and its effects, Zeliger provides acomprehensive reference, a jumping off point for professionals (with extensive chapterbibliographies) and an introduction to the topic for those studying traditional toxicology. Addressing many inadequately understood illnesses and conditions such as asthma,infertility and cancer, it will also be of interest to health professionals, environmentalscientists and lawyers. - Presents a theoretical framework for predicting the effects of chemical mixtures for which no specific data exists (this predictive aspect is important due to the vast number of different potential chemical combinations far too many to comprehensively catalog)- A quick and convenient source of hard to come by data on the rapidly developing field of chemical mixtures, for groups including chemists and engineers, toxicologists, health professionals and environmental scientists- New and updated material comprises over 30% of this timely new edition, which includes the latest research data alongside an expanded introduction to the science and art of predicting the toxicological properties of chemical mixtures