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Himself follows the lives of John and Patrick Donohue, two brothers growing up in the Old First Ward in Buffalo, New York in the mid-1800s. Orphaned as children, they are sent to live with their grandmother. While John finds work and helps support the family, Patrick becomes involved with a gang and runs wild. When the Civil War breaks out, both brothers join the Union army. Follow them through the deadly battles of Grant's Virginia campaign to Appomattox, the difficulties they face holding jobs once the war is over, their relationships with wives, children, and one another, and Patrick's lifelong battle with the bottle. A compelling tale of two Irish Catholic men, sons of immigrants, during a tumultuous period in our nation's rich history.