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    Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy

    Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy

    Af
    Bog E-bog
    • Format
    • Bog, hardback
    • Engelsk

    Beskrivelse

    Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management. This book reviews the latest developments providing insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment.

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  • Vægt730 g
    • coffee cup img
    10 cm
    book img
    15,2 cm
    22,9 cm

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    GRI Er Survival Development Hypertension Inflammation Steroid hormones Glucocorticoids Differentiation Morphogenesis Interferon Cell migration Myocardial infarction Progesterone Biological response modifiers Wound healing Atherosclerosis Pathogenesis MicroRNAs Cell adhesion Metastasis Growth factors Integrins Extracellular matrix Apoptosis Cell differentiation Cell proliferation Domain structure Retinoids Adrenal cortex Stat Invasion Osteocalcin Interleukins Neurogenesis Neuroprotection MCP Tumorigenesis Neurotrophins Therapeutic Potential Wnt Nuclear receptors PI3K BDNF PSA Androgen Hsp90 Hypoxia Vitamin D3 Oestrogens Pattern formation RXR Epithelial-mesenchymal transition Chromatin remodeling Angiogenesis Genetic polymorphism Immune function BRCA1 PTEN G protein-coupled receptors RAS Signalling pathways MMPs Membrane receptors ECM BCL NGF ECM proteins P53 Lapatinib EGF EGFR Fibronectin Triple negative breast cancer Cell motility VEGF Neuronal differentiation HER2 Trk receptors Tissue repair MiRNA TNF Haematological malignancies RAR Cancer progression BPH Erk Herceptin MAPK abl Activin/Inhibin Akt activation anti-angiogenic function Androgen response elements BMP calcium mobilisation in bone amphiregulin Brachyury gene carbohydrate metabolism cell scattering co-activators C/EBP transcription factors central nervous system development domain structure of receptors cytoplasmic receptors EGF-/ER breast cancers embryonic patterning cartilage differentiation CCN family CD36 CD47 epidermal growth-factor group ezrin FGF homologous factors Dimeric isoforms fibroblast growth factor family FLRT proteins Foetal Development Cystine-knot growth factors co-repressors FGF HER4 HGF GDF death receptors IFN-inducible proteins HB-EGF β-cellulin differentiation of bone IRS proteins IGFR HER3 JAK/STAT Intracellular receptors embryonic axis early caudal patterning epiregulin ER/PR GPCR Intercellular adhesion migratory behaviour MCP-1 MET receptors leptin metastasis NF-κB notch signalling osteopontin neuregulins Hh homologues NKX nodal pleiotropic effects non-genomic signalling negative GRE PI3K/Akt RANKL/RANK positive GRE splice isoforms of GR PLC-γ/PKC PDGF prostate-derived factor PTEN/Akt steroid receptor co-activator signalling convergence splice isoforms Retinoic Acid Receptors TGF-β ligands IGFBP module snail of transcription factors Src kinases TRAIL ligand TFF1 (pS2) gene Insulin Receptor VD3 VDR VDRE metastasis promoter genes metastasis suppressor gene metastasis suppressor genes Wnt/β-catenin steroid hormones signal transduction VEGF VWC module Neural differentiation neurite extension TGF TGF-β mitogenicity PI3K/PTEN/Akt myeloid differentiation NF-003BA mammalian target of rapamycin (mTOR) N-CoR oestrogen/progesterone Ras/MAP-kinase Src Ras/RAF/ERK1/MAPK thyroid hormone receptors triple-negative breast cancers TSP1 Ras/ERK/MAPK retinoids SMRT TSR domain tumour cell growth VEGFs
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