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Genome Duplication

  • Format
  • Bog, paperback
  • Engelsk

Beskrivelse

Genome Duplication provides a comprehensive and readable overview of the underlying principles that govern genome duplication in all forms of life, from the simplest cell to the most complex multicellular organism.



Using examples from the three domains of life - bacteria, archaea, and eukarya - Genome Duplication shows how all living organisms store their genome as DNA and how they all use the same evolutionary-conserved mechanism to duplicate it: semi-conservative DNA replication by the replication fork. The text shows how the replication fork determines where organisms begin genome duplication, how they produce a complete copy of their genome each time a cell divides, and how they link genome duplication to cell division.



Genome Duplication explains how mistakes in genome duplication are associated with genetic disorders and cancer, and how understanding genome duplication, its regulation, and how the mechanisms differ between different forms of life, is critical to the understanding and treatment of human disease.

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Detaljer
  • SprogEngelsk
  • Sidetal476
  • Udgivelsesdato06-10-2010
  • ISBN139780415442060
  • Forlag Focal Press
  • FormatPaperback
Størrelse og vægt
  • Vægt997 g
  • coffee cup img
    10 cm
    book img
    21,9 cm
    27,6 cm

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    Evolution DNA Initiation Medicine Disease Adaptation Genome Genomics Immunology Microbiology Molecular biology Replication Tertiary Phylogeny Secondary Mitochondrial DNA Cell division Bacteria Virology Structure Termination Cell cycle Chromatin Biochemistry Topology Synthesis Methylation Origin Relaxation DNA replication Archaea Cell proliferation DNA-binding proteins Mapping Chromosome A-Form Cancer biomarker Budding yeast DNA-POLYMERASE Template Kinetochore Replication origins Triplex Type II Primer Damage response Antibiotic Protein modification DNA Synthesis Epigenetic Bidirectional Replication Fossil record Ligation Genome size Spindle assembly checkpoint Polymerase Anti-Cancer Eukarya Host defense Antiviral Eukaryote Histone Repair Primary FEN1 Genome duplication DNA2 Dna molecule Unwinding Nucleosome Ligase Topo Heterochromatin Cruciform Leading strand abbreviated mitotic cell cycle bent DNA B-form Base pair binary fission CDK Activity chromatid c-form Chromatin assembly DNA polymerase I paradigm Dps protein DnaB DNA Loop Duplex DNA dynamic processivity episome chromatin disassembly family C circularization family D classical replicon model chromatin packaging Fis protein Domains of life functional redundency cmposition conditional replicator family A concatemer formation genetic complexity paradox gyrase hand-off Gap filling C-value paradox damage checkpoint Heritable Disease Helicase helicase loader DNA unwinding Initiator Protein EBV paradigm Initiate DNA Replication Initiate DNA Synthesis DNA helicase DNA Primase jumping back lagging strand synthesis Melvin L. DePamphilis loloenzyme family B MCM Helicase Nascent DNA Leading Strand Synthesis Mitotic cell cycle Nucleosome assembly multiple replication origins nicking nucleotide repeat disorder Nascent DNA Strand helicase-primase paradox Polymerase fidelity Primase protein-nucleotide primer promoting complex iHF protein pharmacological agent reinitiation replication checkpoint Replisome preRC Assembly rolling cycle quadruplux restriction checkpoint RNA-primed sliding clamp slipped-strand DNA replication protein sliding clamp loader supercoil semi-conservative stringent response Rotary Engine termination paradox sister chromatid strand displacement initiator polymerase type ia internal replicator MCM Last Universal Common Ancestor Leading Strand Template Lagging Strand Template Okazaki Fragment Okazaki Fragments noncanonical primer excision nucleotide-associated protein meiotic cell Replication Fork Replicative DNA Helicase Replicative DNA Polymerase replicator polymerase passive replicator topoisomerase ringmaster superhelicity type IB Replication Forks Stephen D. Bell terminal replicator unwinding element Z-DNA
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