Epigenetics and Human Longevity: A Short Introduction

"Epigenetics and Human Longevity" delves into the intricate world of epigenetics, the study of heritable changes that don't alter the DNA sequence but influence gene activity. Beginning with a foundational understanding, the book explores the dynamic nature of the epigenome and its profound implications for aging. Readers are introduced to the revolutionary concept of the epigenetic clock, revealing how lifestyle choices such as diet, exercise, and even stress can influence our biological versus chronological age. The book also dives deep into the potential of caloric restriction and its molecular mechanisms in extending lifespan. Pivotal discussions on histone modifications, transgenerational epigenetic inheritance, and the implications of epigenetic changes in age-related diseases provide comprehensive insights. The text concludes with a forward-looking examination of epigenetic therapies, the potential of pharmacology in longevity, and the ethical considerations therein, making it a holistic resource for understanding the nexus between epigenetics and human aging.