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The report says that important organizational changes are needed at the National Institutes of Health to ensure the agency meets future challenges effectively. In particular, the report advises NIH to devote additional resources to innovative interdisciplinary research that reflects its strategic objectives and cuts across all agency's institutes and centers. The report recommends that Congress should establish a formal process for determining how specific proposals for changes in the number of NIH agencies and centers should be addressed.Table of ContentsFront MatterExecutive Summary1. Introduction2. The Evolution of NIH's Organizational Structure3. New Opportunities, New Challenges: The Changing Nature ofBiomedical Science4. The Organizational Structure of the National Institutes ofHealth5. Enhancing NIH's Ability to Respond to New Challenges6. Accountability, Administration, and Leadership7. Putting Principles into PracticeReferencesAppendix A: Sources of Information Provided to the CommitteeAppendix B: Acronyms and AbbreviationsAppendix C: Committee Member Biographies