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    Dose Optimization in Drug Development

    Dose Optimization in Drug Development

    Forfatter: info mangler
    Bog
    • Format
    • Bog, hardback
    • Engelsk

    Beskrivelse

    This reference provides a concise overview of the key principles in dose selection and optimization and demonstrates applicability to recent successful new drug applications. Compiling key issues and current research on safety, efficacy, and clinical pharmacology, and PK-PD, this volume critically highlights the multidisciplinary nature of drug development and spans the fields of pharmacokinetics, clinical pharmacology, biostatistics, and experimental medicine.

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    Detaljer
    • SprogEngelsk
    • Sidetal320
    • Udgivelsesdato01-05-2006
    • ISBN139781574448085
    • Forlag CRC Press Inc
    • FormatHardback
    Størrelse og vægt
  • Vægt566 g
    • coffee cup img
    10 cm
    book img
    15,2 cm
    22,9 cm

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    Pharmacology Population Selection Pharmacokinetic Maximum Biomarkers Allometric Scaling Surrogate Endpoint Disease progression modeling Clinical Endpoints Class III Acute High Risk CABG Surgery Biomarkers Definitions Working Group CABG Patient CYP2D6 Genotype Clinical endpoints Clinical Utility Index Dosing regimen CYP2D6 Status Interspecies Scaling Em Subject Endpoint JRA Patient Population Pk Model Pk PD Study Plasma Concentrations Starting Dose surrogate NHE Inhibition Phase IIb Study Population Pk PD Modeling Median AUC RR Interval
    Machine Name: SAXO081