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Design Considerations for Evaluating the Impact of PEPFAR is the summary of a 2-day workshop on methodological, policy, and practical design considerations for a future evaluation of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) interventions carried out under the President's Emergency Plan for AIDS Relief (PEPFAR), which was convened by the Institute of Medicine (IOM) on April 30 and May 1, 2007. Participants at the workshop included staff of the U.S. Congress; PEPFAR officials and implementers; major multilateral organizations such as The Global Fund to Fight AIDS, Malaria, and Tuberculosis (The Global Fund), the Joint United Nations Programme on HIV/AIDS (UNAIDS), and the World Bank; representatives from international nongovernmental organizations; experienced evaluation experts; and representatives of partner countries, particularly the PEPFAR focus countries. The workshop represented a final element of the work of the congressionally mandated IOM Committee for the Evaluation of PEPFAR Implementation, which published a report of its findings in 2007 evaluating the first 2 years of implementation, but could not address longer term impact evaluation questions.Table of ContentsFront MatterOverview1 Introduction to Impact Evaluation for PEPFAR2 Envisioning a Meaningful Impact Evaluation for PEPFAR: MovingBeyond Counting3 Designing an Evaluation That Incorporates the Guiding Principlesof Coordination, Harmonization, and Capacity Building4 Designing an Impact Evaluation with Robust MethodologiesAppendix A: AgendaAppendix B: Abbreviations and AcronymsAppendix C: List of ParticipantsAppendix D: References