Correlation between p53 and MDA in CaP

Prostate cancer (CaP) is most commonly diagnosed non-dermatological solid malignancy with a high metastatic rate. The growing prevalence of cancer survivors was estimated to be over 28 million worldwide. p53 has an important role in CaP. It plays an critical role in cancer metastasis. Serum malondialdehyde (MDA) is a convenient in vivo index of lipid peroxidation. It is a non-invasive biomarker of oxidative stress. Current study was designed to determine correlation between expression of p53 and MDA levels in CaP as compared to normal control. This is a Cross-sectional analytical study which was conducted at Department of Biochemistry & Molecular Biology & Department of Urology, Rawalpindi, National University of Science and Technology, Islamabad over a period of one year. Study included 26 samples. Expression of p53 and levels of MDA were determined by real time qPCR and ELISA technique respectively. It has been seen that CaP is an age related disease. We have compared mean value of MDA in CaP and control group. We have compared mean CT value of CaP with control group. There was a weak inverse correlation between expression of p53 and MDA in CaP group.