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This textbook details how mental health and addiction are interconnected through childhood trauma, how this affects neurobiology and neuropsychology, and the need for an integrated whole-person treatment for those of diverse backgrounds to enhance treatment outcomes. Using an integrative pedagogy, the book helps readers broaden their understanding of co-occurring disorders through case studies, learning objectives, key terms, quiz questions, suggested resources, and references. By linking to previous knowledge and suggesting practical applications, each chapter provides clear direction for learning more about each treatment approach, diagnosis, and population discussed within the multicultural and biopsychosocial perspective. Co-occurring Mental Illness and Substance Use Disorders will help graduate students in both substance use and mental health counseling make sense of integrative treatment with co-occurring disorders.