Cannabidiol for neuroprotection in hypoxic-ischemic encephalopathy

Cannabidiol, administered at 1mg/kg up to 18 h after hypoxia ischemia prevents the resulting brain damage, protecting neurons and astrocytes, protecting myelinization , restoring brain activity and function and preventing behavioural consequences. Cannabinoid CB2 receptors are somehow involved in these effects. Serotonin 5HT1A receptors are involved in the cannabidiol histological, biochemical and motor protective effects and mediate the behavioural effects of cannabidiol.