Calcium Signaling, Second Edition

Calcium ions play a critical role in signaling in a wide variety of cells and tissues, including muscle, immune cells, neurons, the liver, and oocytes. This new volume explores the channels and pumps that transport calcium, calcium buffers and sensors, and how these produce distinct spatiotemporal signals in different circumstances. It covers calcium signaling during development and normal physiology, as well as perturbed signaling in diseases such as diabetes, neurodegeneration, and atherosclerosis. Topics covered include:

- The role of SERCA/SPCA/and PMCA

- Mitochondria in calcium signaling

- Organellar Calcium Handling in the Cellular Reticular Network

- Calcium Sensors in Neuronal Function and Dysfunction

- The Calcium Signaling Toolkit in Cancer: Remodeling and Targeting