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Brain Edema

- From Molecular Mechanisms to Clinical Practice

Forfatter: info mangler
Bog
  • Format
  • Bog, hardback
  • Engelsk

Beskrivelse

Brain Edema: From Molecular Mechanisms to Clinical Practice brings together the most widely recognized experts in experimental and clinical brain edema research to review the current knowledge gathered on the molecular and cellular pathophysiology and clinical management of brain edema. This timely book also discusses future directions of research and treatment. Brain edema is an integral and acutely life-threatening part of the pathophysiology of multiple cerebral and non-cerebral disorders, including traumatic brain injury, cerebral ischemia, brain tumors, cardiac arrest, altitude sickness and liver failure. Affecting millions worldwide, research over the past few years has shown that a plethora of complex molecular and cellular mechanisms contribute to this pathological accumulation of water in the brain parenchyma. In parallel, the development of new neuroimaging tools has provided a new way to examine how edema develops longitudinally and in real time, both in pre-clinical models and in patients. Despite intense research over the past few decades, therapeutic options are still limited and sometimes not effective.

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Detaljer
  • SprogEngelsk
  • Sidetal554
  • Udgivelsesdato08-07-2017
  • ISBN139780128031964
  • Forlag Academic Press Inc
  • FormatHardback
Størrelse og vægt
  • Vægt1000 g
  • coffee cup img
    10 cm
    book img
    15,2 cm
    22,9 cm

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    Brain Epilepsy Ion channels Cerebrospinal Fluid Cell death Glioblastoma Neurodegenerative Diseases Hypothermia Homeostasis Gliomas Regulation Diffusion Brain tumors Pathogenesis Brain Edema Blood-brain barrier Permeability Choroid plexus Microcirculation Extracellular matrix Cerebral edema Hydrocephalus Ammonia Endothelial Cells Extracellular Space Intracranial hypertension Intracranial pressure Astrocytes Edema Aquaporins Matrix Metalloproteinases Brain metastasis Mannitol Multimodal Imaging Penumbra Neuroprotection In vitro models Diffusion Weighted Imaging Cerebral Vessels Cerebral blood flow Neuroinflammation Biomarkers Dexamethasone Glia Computed tomography Cell volume Glial cells Aquaporin Astrocyte Acute liver failure BBB breakdown Blood-Brain-Barrier Disruption Spinal cord injury Brain imaging Clinical symptoms Channels Impedance Cerebrovasculature 2-photon microscopy Aquaporin-4 Brain water balance Cellular demand Cerebral vascular endothelium Assessment of brain edema in vivo Cell volume regulation Cytotoxic brain edema Cytotoxic edema Brain herniation Brain swelling Decompressive Craniectomy Cerebral arginine vasopressin receptor Cerebral perfusion Cerebral vascular permeability factor Dystrophin Edema fluid clearance Clinical translation of brain edema treatment External ventricular drainage Glymphatic system Inorganic ions Ion gradients Inhibition of astrocytic ion transporter Ionic edema Experimental therapy for ischemic penumbra Neuronal activation Glibenclamide Functional integrity Perivascular spaces Hypertonic Saline Perivascular space Raised intracranial pressure Ion transporters SUR1-TRPM4 Neuro-vascular unit Neurovascular Unit Prognosis treatment Microvascular failure Neurosteroids
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