Automated Drug Delivery in Anesthesia

Pharmacokinetics Automatic control Pain Nonlinear Dynamics OPTIMIZATION Multiscale modeling Patient safety Pharmacodynamics Open-loop control Closed Loop Control Fractional Order Modeling Anomalous diffusion Model-predictive control Mathematical model Stability Analysis Delivery systems Nociception Identifiability Evolutionary algorithms Skin Impedance Cyber Medical Systems Model verification Impedance measurement analgesia monitors Anesthetic depth compartment model Depth-of-Hypnosis control complete anesthesia system continuous fraction expansion fractional-order impedance model drug administration interpatient variability fractional order control Neuromuscular Blockade non-newtonian interface platform robustness to inter- and intra-patient variability simplified drug model total mass control tissue porosity on-line identification method rocuronium pharmakokinetic/pharmakodynamic model total intravenous anesthesia regulation