Association between hepcidin, ferroportin and iron metabolism

Iron is the necessary molecule for cellular metabolism and is an imperative nonorganic substance, that plays a major role inoxygentransport, short-term oxygen storage., electron transfer, DNA synthesis and cell cycle phase transitioning. Iron¿s physiological importance, however, is primarily determined by its oxidative state, where it has the ability to change between its ferrous (Fe2+) and ferric (Fe3+) form. Human hepcidin is predominantly produced by hepatocytesas a 25 amino acid peptide (2789.4 Da) that is secreted into the circulation.