Advances in The Chemistry and Applications of Fluoroquinolones

Quinolones are an substantial species of wide scale antibacterial drugs, which has the fundamental structure 1,4 dihydro-4-oxo-quinolinyl part holding a carboxy moiety at location three. Historically the chemistry of quinolones beginning with the appearance of Nalidixic acid for medication of urinary tract diseases in human being 1962. First discovery was by George Lesher and his colleagues. It was obtained from antimalarial agent chloroquine One of the most auspicious and attractive concurrent fields of modern medication are Fluoroquinolones which describing a wide scale and best potent results. They have a comparatively small nucleus that can be developed to various conformation. These new compounds have various convenient aspects such as great reactivity and low toxicity. These bioorganic molecules have superior effectivity against several pathogens. This book focuses on some of the therapeutic aspects of fluoroquinolone antibacterial activity with an updated status on their modifications, structural activity relationship, antiviral, anticancer activity.