Advances in Computers

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics, including HAMLET and tumor cells; survivin and apoptosis control; retroviral insertional mutagenesis; aberrant ubiquitin-mediated proteolysis of cell cycle regulatory proteins and oncogenesis; and epigenetic variability and the evolution of human cancer.Since 1960, Advances in Computers has chronicled the constantly shifting theories and methods of Information Technology which greatly shapes our lives today. This volume, the 59th in the series, presents two general themes. The first 4 papers discuss tool use in developing software - how groups work together to produce a product, and why the very industries that need them often do NOT adopt such tools. The fifth paper addresses a current hardware issue - cache coherence. As we build faster machines, a way to increase performance is to have multiple CPUs working on solving the same problem. This requires two or more CPUs to address the same memory at the same time. The cache coherence problem is how to allow both machines to access the same memory without "stepping on each others toes" so that memory gets lost or corrupted.