Pharmacogenomics: Foundations, Competencies, and the Pharmacists' Patient Care Process

Pharmacogenomics: Foundations, Competencies, and the Pharmacists' Patient Care Process provides a basic and clinical foundation for the application of drug-gene interactions in clinical therapeutics. As the field of PGx advances, there is a need for a pharmacy-based, directed resource that can be a reference for practicing pharmacists and student pharmacists. Specific information is presented through 'PGx Pearls.' Each of the 17 cases are presented in the context of the PPCP, with 'Competency Connections' related to genetics and genomics. Each of the 29 chapters providescontent and objective related questions with the answers provided. Two appendices are included. KEY FEATURES:i Connects the clinical application with basic foundational principles of pharmacogenomicsi Includes pharmacogenomics case studies across therapeutic areasi PPCP-focused content that reinforces the pharmacists' role in pharmacogenomicsi Ideal for adoption in courses teaching pharmacogenomics and pharmacogenetics Chapter 1. Foundations of PharmacogenomicsChapter 2. Pharmacogenomics: Drug Exposure and ResponseChapter 3. Pharmacists Competencies in Genetics/GenomicsChapter 4. Information Resources for PharmacogenomicsChapter 5. Implementation of Pharmacogenomics across Practice SettingsChapter 6. The Pharmacists' Patient Care Process (PPCP)Chapter 7. Cardiology: Clopidogrel/CYP2C19 CaseChapter 8. Cardiology: Simvastatin/SLCO1B1 CaseChapter 9. Cardiology: Warfarin/CYP2C9, VKORC1, CYP4F2 CaseChapter 10. Endocrinology: Glipizide/G6PD CaseChapter 11. Immunology: Tacrolimus/CYP3A5 CaseChapter 12. Infectious Diseases: Abacavir/HLA-B CaseChapter 13. Infectious Diseases: Atazanavir/UGT1A1 CaseChapter 14. Infectious Diseases: Voriconazole/CYP2C19 CaseChapter 15. Neurology: Carbamazepine/HLA-A, HLA-B CaseChapter 16. Neurology: Phenytoin/CYP2C9, HLA-B CaseChapter 17. Oncology: Somatic Disease and PharmacogenomicsChapter 18. Oncology: Mercaptopurine/TPMT CaseChapter 19. Oncology: Fluorouracil/DPYD CaseChapter 20. Oncology: Rasburicase/G6PD CaseChapter 21. Psychiatry: Amitriptyline/CYP2C19, CYP2D6 CaseChapter 22. Psychiatry: Paroxetine/CYP2D6 CaseChapter 23. Respiratory: Ivacaftor/CFTR CaseChapter 24. Rheumatology/Musculoskeletal Pain: Allopurinol/HLA-B CaseChapter 25. Rheumatology/Musculoskeletal Pain: Azathioprine/TPMT, Celecoxib/CYP2C9 CaseChapter 26. Rheumatology/Musculoskeletal Pain: Codeine/CYP2D6 CaseChapter 27. Pharmacogenomics TestingChapter 28. Pharmacogenomics in Ethical and Social ContextsChapter 29. Pharmacogenomics and Secondary/ Incidental FindingsAppendix 1: Competency ConnectionsAppendix 2: Glossary