Concepts and Models for Drug Permeability Studies

Drug development In vitro Diffusion Modeling Skin Blood-brain barrier Permeability Central Nervous System Carcinoma Absorption Monoculture Nonhuman primates In vitro models Drug-Delivery Biopharmaceutical Dynamic Model Primary cell cultures Retinal pigment epithelium Microflora Drug Absorption Cell permeability Intestinal permeability Gastric Diffusion cell Gastrointestinal Vaginal Co-culture Buccal Buccal permeability studies Buccal drug delivery Cell isolation and immortalization cell model Cerebral Microvessels Conjunctiva epithelium cell culture model Correlation in vitro-in vivo Buccal mucosa model Caco-2 cells Dermal permeation Cell culture-based models EpiDermâ„¢ Everted intestinal ring EpiSkinâ„¢ Excised animal corneas Excised nasal mucosa models Ex vivo approach Cornea cell culture model Guidelines in vitro methodologies Hamster cheek pouch cells Immortalized culture drug permeability HT29-MTX cells EpiDerm FTâ„¢ Intranasal route In vitro approach In vitro-in vivo correlation Ex vivo lung model Everted intestinal sac Nasal cell lines Nasal Mucosa Localized drug delivery Franz diffusion cell Oral keratinocytes Nasal epithelium Paracellular Ocular cell culture Primary cultures Permeability studies Permeability/absorption Isolated perfused lungs Pulmonary absorption Pulmonary administration In vitro absorption In vitro permeability StrataTestâ„¢ Skin membranes Targeting to the central nervous system Immortalized endothelial cell lines Systemic drug delivery Vaginal mucosa Three-dimensional cornea constructs Transferability to human Permeation experiments Retinal capillary endothelium Porcine Buccal Mucosa OCULAR DRUG DELIVERY SkinEthicâ„¢ RHE model Pulmonary permeability Raji B cells Topical application Permeation parameters Tissue culture-based models Ussing chamber TR146 cell line Transcellular Vaginal drug delivery